Experimental Allergic Encephalomyelitis and the "Auto-Allergic" Diseases

Autoimmune diseases and thalidomide. I. Experimental allergic encephalomyelitis and experimental allergic neuritis of the guinea pig.

The teratogenic effect of thalidomide (Th) is well-known. Current theories about the mechanism of action of this effect have been well summarized by Woollam (21), There is controversy about the possible immunosuppressive action of this compound (1 , 2,4,5, 10) and its influence on chromosome aberrations (9. 14. 15). It seems clear, however, that the drug does not have an all-inclusive "blanket"...

Alpha-fetoprotein suppresses experimental allergic encephalomyelitis.

Experimental allergic encephalomyelitis (EAE), induced in guinea pigs by immunization with myelin basic protein (MBP) or whole CNS homogenate was successfully treated, as well as partially prevented, by daily administration of fetal alpha-fetoprotein (alpha FP). alpha FP which is produced in high quantities during pregnancy can inhibit both the cell-mediated immune response to MBP and the bindi...

MR of acute experimental allergic encephalomyelitis.

Acute experimental allergic encephalomyelitis, an animal model of CNS inflammatory and demyelinating disease, was produced in guinea pigs and imaged with MR. Correlation of histopathology with MR revealed acute mononuclear perivascular inflammatory changes and edema corresponding to the high-intensity abnormalities observed on long repetition time (TR) images. Our results suggest that in acute ...

Metabolomics approaches in experimental allergic encephalomyelitis.

A myelin basic protein (MBP)-induced experimental allergic encephalomyelitis (EAE) involves paraplegia due to a reversible thoracolumbar spinal cord impairment. The aims of this study were thus to find significant metabolic biomarkers of inflammation and identify the site of inflammation in the central nervous system (CNS) during the acute signs in of the disease using metabolomics. All the EAE...

Experimental Allergic Encephalomyelitis in Oxygen Immunosuppression : Modification